A team of Canadian scientists has found a way to break the barrier of the human body that keeps the nervous and circulatory systems apart, and inject the drugs directly into the brain using “carrier” antibodies.
That system known as the blood-brain barrier (BBB) protects the human skull from any microbes or chemicals, thus keeping the brain clean.
But this barrier also filters good things, such as disease fighting drugs from entering the nervous system. It only allows a selected few types of molecules to cross including water, some gases and lipid soluble molecules.
Scientists from the Canadian National Research Council have been battling for years to find a way to trick it and get the drugs to where they are most needed – to the human brain.
Currently, researchers say they have found a way based on the so-called “single domain antibodies” (SDA). It includes using special molecular fragments that are capable of tricking the blood-brain barrier (BBB) and making it believe they should be let through to the brain. The antibodies are able to squeeze past the barrier not just because of their size (these are fragments that consist of one molecule) but also due to being familiar to some of the receptors along the blood-brain barrier.